ORGANIZATION:

SPECIALTY GROUP ON NEUROEPIDEMIOLOGY, WORLD FEDERATION OF NEUROLOGY

SECCIÓN NEUROEPIDEMIOLOGÍA, INSTITUTO DE NEUROLOGÍA, MONTEVIDEO, URUGUAY

CENTRO UNIVERSITARIO REGIONAL DEL ESTE (C.U.R.E.), UNIVERSIDAD DE LA REPÚBLICA

COORDINATION:

• Dr. Carlos N. Ketzoian (Uruguay)
CHAIRMAN SPECIALTY GROUP ON NEUROEPIDEMIOLOGY WFN, SECCIÓN NEUROEPIDEMIOLOGÍA, INSTITUTO DE NEUROLOGÍA
• Dr. Fernando Gracia (Panamá)
VICE PRESIDENT OF LACTRIMS - UNIVERSIDAD INTERAMERICANA DE PANAMÁ
• Dr. Mario O. Melcon (Argentina)
EPIDEMIOLOGY COORDINATOR APPOINTED TO THE EXECUTIVE COMMITTEE OF LACTRIMS - F.I.N.E.P. (Fundación para la Investigación en Neuroepidemiología) – JUNIN – ARGENTINA
• Dra. Regina Alvarenga Papais
PROFESSOR OF NEUROLOGY – FEDERAL UNIVERSITY OF THE STATE OF RÍO DE JANEIRO (UNIRIO) BRAZIL

LOCAL COORDINATION GROUP:
• Dr. Fabián Gómez
• Dra. Valeria Rocha
• Dra. Noelia Sorondo
• Dra. Lucía Castro

TEACHING TEAM:

• Professor WALTER A. ROCCA
M.D., M.P.H., PROFESSOR OF EPIDEMIOLOGY AND NEUROLOGY, MAYO CLINIC, COLLEGE OF MEDICINE AND CO-DIRECTOR OF THE ROCHESTER EPIDEMIOLOGY PROJECT, ROCHESTER, MINNESOTA, U.S.A.

• Professor GIANCARLO LOGROSCINO
DIRECTOR OF THE DEPARTMENT OF CLINICAL RESEARCH IN NEUROLOGY, UNIVERSITY OF BARI, FONDAAZIONE PANICO TRICASE, ITALY.

• Professor PIERRE MARIE PREUX
DIRECTOR OF THE INSTITUT OF NEUROEPIDEMIOLOGY AND TROPICAL NEUROLOGY (IENT), LIMOGES, FRANCE.

• Professor RUTH OTTMAN
Ph. D. PROFESSOR OF EPIDEMIOLOGY IN NEUROLOGY AND THE SERGIEVSKY CENTER. DEPUTY DIRECTOR FOR RESEARCH, G.H. SERGIEVSKY CENTER. COLUMBIA UNIVERSITY. NEW YORK. U.S.A.

• Professor FELICITY ENDERS
Ph. D. PROFESSOR OF BIOSTATISTICS, MAYO CLINIC COLLEGE OF MEDICINE, ROCHESTER, MINNESOTA, U.S.A.

GUEST SPEAKERS

GUEST SPEAKERS:

Professor Riadh Gouider (Tunisia) – World Federation of Neurology - Trustee
Professor Regina Alvarenga Papais (Brasil) – University of Río de Janeiro
Professor Sergio Baranzini (U.S.A.)
Professor Jorge Correale (Argentine)

Language

The course will be taught in English.
The conferences will be in English, Portuguese or Spanish.

Objectives of the course

• To discuss the characteristics of different types of surveys: population surveys, analytic studies and clinical trials, with particular emphasis in multiple sclerosis.
• To introduce to genetic epidemiology and to understand the bases of gene- environment interaction.
• To review the main aspects of statistics applied to epidemiological research, with emphasis on importance versus significance, and confounding factors and interaction.
• To exchange experiences and opinions between researchers on MS in Latin America, and introduce the discussion about the opportunity and feasibility of a muticentric survey in the region.
• To give the opportunity to discuss neuroepidemiological studies in different processing phases (preparation, implementation, data analysis, etc.) with researchers with experience
The complex building of current clinical research continues to stand on four methodological pillars – the population surveys, the case-control study, the cohort study and the clinical trial. These four methods, along with their combinations and modifications, enable us to investigate any possible cause-effect relationship across 1) biological, personal, or social factors or events, 2) symptoms, diseases, or conditions, and 3) treatments, procedures, or interventions. This 5 day course provides a review to the four methods, with emphasis on their complementarities and their relative strengths and weaknesses. As such, the course will enable the participants to better understand how evidence is constructed in clinical research. Participants will improve their ability to design, conduct, and interpret studies, and to write and read scientific papers and grant applications.

Methodology

The course methodology is based on:
• Lectures
• Example’s discussion about different types of surveys
• Analysis of papers published with different study’s designs
• Presentation of neuroepidemiological surveys carried on Latin America by the authors
• Discussion in workshops
• Conferences

A syllabus will be distributed to participants two weeks before the start of the course

Participants

Minimum 30
Maximum 50

Program DAY 1

DAY 1 – SUNDAY 03/15/2020

ARRIVAL AND ACCOMMODATION

Program DAY 2

DAY 2 – MONDAY 03/16/2020

Morning – SURVEYS IN NEUROEPIDEMIOLOGY (8:30 – 12:15)
8:30 – 8:40 – WELCOME
8:40 – 9:00 – INTRODUCTION TO THE COURSE
9:00 – 9:45 – BASIC IDEAS AND TERMINOLOGY
9:45 – 10:30 – POPULATION SURVEYS (PART 1)
10:30 – 11:00 – Coffee Break
11:00 – 11:45 – POPULATION SURVEYS (PART 2)
11:45 – 12:15 – GENERAL DISCUSSION

12:15 – 14:00 – Lunch Break

Afternoon – (14:00 – 18:30)
14:00 – 16:15 – HOW TO READ A PAPER – a descriptive survey 16:15 – 16:30 – Coffee Break

16:30 – 17:15 –NEUROEPIDEMIOLOGIC STUDIES IN DEVELOPING COUNTRIES
17:15 – 18:00 – OPENING CONFERENCE: EPIDEMIOLOGY OF MS: LESSONS FROM AFRICA AND MIDDLE EAST – PROFESSOR RIADH GOUIDER – WFN TRUSTEE
18:00 – 18:30 – GENERAL DISCUSSION

Program DAY 3

DAY 3 – TUESDAY 03/17/2020
Morning – ANALYTIC STUDIES (9:00 – 12:15)
9:00 – 9:45 – ANALYTIC STUDIES: OVERVIEW
9:45 – 10:30 – CASE-CONTROL STUDIES
10:30 – 11:00 – Coffee Break
11:00 – 11:45 – COHORT STUDIES
11:45 – 12:15 – GENERAL DISCUSSION

12:15 – 14:00 – Lunch Break

Afternoon – (14:00 – 18:30)
14:00 – 16:15 – HOW TO READ A PAPER – a case-control study 16:15 – 16:45 – Coffee Break

16:45 – 17:30 – CAPTURE – RECAPTURE METHOD
17:30 – 18:15 – CONFERENCE: WHAT POSSIBILITIES OF RESEARCH TRAINING IN NEUROEPIDEMIOLOGY IN LATIN AMERICA? THE EXPERIENCE OF THE UNIVERSITY OF RÍO DE JANEIRO – PROFESSOR REGINA ALVARENGA PAPAÏS (UNIRIO)
18:15 – 18:30 – GENERAL DISCUSSION

 

Program DAY 4

DAY 4 – WEDNESDAY 03/18/2020
Morning – CLINICAL TRIALS (9:00 – 12:15)
9:00 – 10:30 – CLINICAL TRIALS
10:30 – 11:00 – Coffee Break
11:00 – 11:30 - INFERENCES FROM EPIDEMIOLOGIC RESEARCHES
11:30 – 12:15 – GENERAL DISCUSSION

12:15 – 14:00 – Lunch Break

Afternoon – (14:00 – 18:30)
14:00 – 16:15 – HOW TO READ A PAPER – a cohort study 16:15 – 16:30 – Coffee Break
16:30 – 17:15 – CONFERENCE: STUDIES IN MULTIPLE SCLEROSIS IN CENTRAL AMERICA: THE EXPERIENCE OF FOCEM – PROFESSOR FERNANDO GRACIA (PANAMÁ)
17:15 – 17:30 – NEUROEPIDEMIOLOGY OF M.S. IN PARAGUAY
17:30 – 17:45 – INCIDENCE OF MS IN URUGUAY. PRELIMINARY RESULTS - EMELAC URUGUAY
17:45 – 18:15 – EPIDEMIOLOGY OF NMO IN RÍO DE JANEIRO – PROFESSOR REGINA ALVARENGA

18:15 – 18:30 – GENERAL DISCUSSION

Program DAY 5

DAY 5 – THURSDAY 03/19/2020
Morning – GENETIC EPIDEMIOLOGY (9:00 – 12:15)
9:00 – 10:30 – INTRODUCTION TO GENETIC EPIDEMIOLOGY (PART 1)
10:30 – 11:00 – Coffee Break
11:00 – 11:45 – INTRODUCTION TO GENETIC EPIDEMIOLOGY (PART 2)
11:45 – 12:15 – GENERAL DISCUSSION

12:15 – 14:00 – Lunch Break

Afternoon – (14:00 – 18:30)
14:00 – 16:15 – HOW TO READ A PAPER – a clinical trial 16:15 – 16:45 – Coffee Break
16:45 – 17:30 – GENE-ENVIRONMENT INTERACTION
17:30 - 18:00 – NEUROEPIDEMIOLOGY OF MS IN ARGENTINA – PROFESSOR MARIO O. MELCON
18:00 – 18:30 – GENERAL DISCUSSION

Program DAY 6

DAY 6 – FRIDAY 03/20/2020
Morning – STATISTICS AND EPIDEMIOLOGY (9:00 – 12:15)
9:00 – 9:45 – USE AND MISUSE OF STATISTICS IN EPIDEMIOLOGY
9:45 – 10:30 – IMPORTANCE VERSUS SIGNIFICANCE
10:30 – 11:00 – Coffee Break
11:00 – 11:45 – CONFOUNDING AND INTERACTION
11:45 – 12:15 – GENERAL DISCUSSION

12:15 – 14:00 – Lunch Break

14:00 – 14:45 – CONFERENCE: "INTEGRATION OF ELECTRONIC MEDICAL RECORDS WITH A KNOWLEDGE NETWORK TO ENABLE MULTI-SCALE UNDERSTANDING OF NEUROLOGICAL DISEASES" – PROFESSOR SERGIO BARANZINI (U.S.A.)
14:45 – 15:30 – CONFERENCE: “EL IMPACTO DE LOS FACTORES
AMBIENTALES EN EL DESARROLLO Y CURSO DE ESCLEROSIS MÚLTIPLE”
– PROFESSOR JORGE CORREALE (Argentina) 15:30 – 16:15 – SURVIVAL STUDIES
16:15 – 16:45 – Coffee Break
16:45 – 17:30 – SURVIVAL STUDIES: EXERCISES
17:30 – 18:00 - CLOSURE OF THE COURSE

Program DAY 7

DAY 7 – SATURDAY 03/21/2020
DEPARTURE

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